Endocrine Abstracts

Pituitary adenomas represent more than 80% of all sella turcica tumors and 10–15% of all intracranial tumors in adults. Topoisomerase II α (TopoIIα) is recognized as a reliable tumor proliferative activity marker. Evaluation of its expression facilitates the identification of more aggressive neoplasms.Aim: To assess the topoIIα expression in pituitary adenomas as the marker of the tumor aggressiveness, recurrence and progression.<...

In many neoplasms, excessive angiogenesis is prognostic factor, independent from proliferation. Previous studies confirmed correlation between cyclooxygenase-2 (COX-2) expression and micro-vascularization density in pituitary tumors. Moreover, nonsteroidal anti-inflammatory drugs have strong inhibiting effect on COX-2 expression and possible anti-tumor activity.Aim: To assess COX-2 expression in pituitary adenomas, its relation to adenoma type as well as...

Introduction: Among three types of gastric neuroendocrine tumors (GEPNETV) type 1 are most common. At the basis of the pathogenesis of type 1 is atrophic gastritis, which leads to achlorhydria and deficiency of intrinsic factor, resulting in G cell hyperplasia and hypergastrinaemia. Gastric endoscopy usually reveals the multiple and polypoid lesions (<1–2 cm) in the corpus. Five-year survival in these patients is not different from survival in the selected age group p...

Introduction: During clinical observation the behaviour of pituitary tumours is frequently unpredictable. The work was aimed at evaluating Ki-67 and topoisomerase II alpha indices as markers of tumour invasiveness and prognostic factors for postoperative course of disease.Material and methods: The Ki-67 and topoisomerase IIα (Topo IIα) indices were determined by immunochemistry in specimens excised from neurosurgically removed pituitary tumours...

Introduction: The autoimmune process is currently the most common cause ofthe primary adrenal insufficiency cases in developed countries. The complexity of this process consists of genetic, immunological and environmental factors. It has been proven that vitamin D (VD) inhibits the production of inflammatory cytokines and can modulate immune-regulatory mechanisms.Purpose: The aim of our study was to evaluate the prevalence of VD insufficiencyin...

Background: Type 3 neuroendocrine tumors of the stomach (type 3 NETV) are very rare subtypes of NETV with poor prognosis, not fully understood biology and not well investigated diagnostic and therapeutic procedures. The aim of the study was to analyze tumor biology and the outcome of differentiated treatment in patients with type 3 neuroendocrine tumors of the stomach.Methods: A prospective 10 years follow up of five patients with type 3 NETV treated in ...